Scientist, Platform Biology

Company Summary:

FL89, Inc. is a privately held early-stage company that is leveraging advanced biological and computational tools to develop breakthroughs in our understanding of secreted protein function and regulation in human physiology. More specifically, FL89 is pairing high throughput -omics technology with AI/ML based protein structure prediction to define and discover novel therapeutic protein biology.

Flagship Pioneering has conceived of and created companies such as Moderna Therapeutics (NASDAQ: MRNA), Editas Medicine (NASDAQ: EDIT), Omega Therapeutics (NASDAQ: OMGA), Seres Therapeutics (NASDAQ: MCRB), and Indigo Agriculture. Since its launch in 2000, Flagship has applied its unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures. In 2021, Flagship Pioneering was ranked 12th globally on Fortune’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies.

Position Summary:

Part of a collaborative team with a focus on developing high-throughput next-generation sequencing platforms and cell models to enable discovery in the FL89 secretome platform. This individual will utilize previous experiences in generation and analyses of large next-generation sequencing datasets to drive development of a novel biological platform. The position will provide a unique opportunity to play a foundational role in the development of FL89’s preclinical platform.

Key Responsibilities:

• Play a key role in developing, automating, and integrating new high throughput assay technologies into the FL89 Discovery Platform.
• Conceive, build, and optimize novel cell systems and generate NGS libraries at scale.
• Operate and execute cell stimulation and NGS library pipelines in high throughput.
• Track and maintain excellent data records in formats amenable to computational workflows.
• Maintain a meticulous electronic notebook and provide clear plans for upcoming experiments.
• Design, execute, and troubleshoot experiments as well as data analysis.
• Maintain lab notebooks and report data and analysis results to the scientific team.

Basic Requirements:

• Graduate degree in biology, bioengineering, biochemistry, or a related field
• 2+ years of prior research experience in molecular biology and mammalian cell culture
• 2+ years in high-throughput protein biology
• Strong familiarity with sterile technique and thawing, culture, and freezing of mammalian cells
• Understanding of key principles of biological data analysis and statistics
• Strong experience in assay development, miniaturization and performing HTP screens, using primary/stem cells, preferably in industry.
• Experience with cellular readouts such as luminescence, cell viability, fluorescence, ELISA, flow cytometry, high content imaging, etc.
• Strong analytical and problem-solving skills are a must!
• Must have strong attention to detail in a rapidly changing environment 
• Adaptability, resourcefulness, and strong verbal communications skills will be necessary to integrate into this team environment 

Preferred Requirements:

• Prior research experience in industry

• Prior experience with NGS library processing and Illumina instruments.
• Knowledge of NGS data analysis, especially QC metrics including FASTQC and downstream processing

Flagship Pioneering is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.