Scientist, Nonviral Delivery Analytics

The Role:

Life Edit seeks a nonviral LNP analytical development scientist with relevant experience in academia/industry. The selected candidate will support the lipid nanoparticle (LNP) formulation by characterizing formulations (LNP loaded with Life Edit’s novel RNA-guided nucleases (RGNs)/RNPs) as they move from research to preclinical evaluation and eventual clinical advancement. The candidate should possess strong organizational and communication skills and the desire to be part of a highly collaborative and cross-functional team.

Here’s What You’ll Do:

• As part of the nonviral delivery formulation team, you will design, develop, and optimize Life Edit’s RNA/RNP nanoparticle characterization and stability assays using state-of-the-art methods.
• Characterize the RNA/RNP encapsulated LNPs for their size, zeta potential, morphology, encapsulation efficiency, integrity, and stability using relevant assays (DLS, TEM, Ribogreen, CE, AGE, PAGE, UV-VIS, HPLC, etc.).
• Work closely with RNA production, LNP/RNP formulation, and in vitro and in vivo team members.
• Ensure adequate rigorous laboratory practices and documentation in a regulatory-ready research manner
• Evaluate, interpret, and compile LNP characterization data into study reports for potential regulatory filings
• Critically summarize and present data internally to interdisciplinary teams as well as externally.
• Write study specific procedures for analytical methods, protocols, and reports and provide training on processes and equipment.

Requirements:

• PhD in biological sciences, chemistry, material science, bioengineering, chemical engineering, or related sciences with at least a year of relevant experience or MS with at least 8+ years of relevant experience.
• Must have hands on experience in RNA nanoparticle formulation, purification, and characterization assays in academia or direct experience in a biotechnology company.
• Must have knowledge and experience in nanoparticle bioanalytical skills such as nanoparticle characterization and RNA/RNP quantitation assays (DLS, TEM, CE, PAGE, AGE, UV-Vis, and HPLC).
• Experience working with CRISPR or base editing systems, and RNPs preferred
• Demonstrates effective decision-making to steward and prioritize activities to support bench to bedside development programs
• Produce formal reports for internal use and regulatory filings
• Good verbal and written communication skills

We’re committed to finding the best ways to support our teams so they can do their best work. We take care of our employees, right from the start.

Health & Wellness

• Medical, vision, and dental insurance covered at 90%
• Low deductible, no co-insurance and no copays for mental health visits (for in-network care)
• Annual fitness reimbursement
• Employer paid for access to wellness apps and programs like Task Human

Financial

• Competitive compensation
• 401(k) retirement plans with a 4% employer match and no vesting period
• Employer-paid life insurance and short- and long-term disability insurance
• Employer-sponsored flexible spending accounts (FSA) and dependent care account (DCA)
• Access to a 1-on-1 financial advisor
• Commuter reimbursement benefit
• Monthly cell phone stipend

Time Off & Flexibility

• Unlimited paid time off, including vacation, sick leave, family leave, personal days, and bereavement
• 18 paid company holidays, plus an end-of-year holiday shut down
• 12 weeks of parental leave
• Federal Family and Medical Leave Act (FMLA) and Massachusetts Paid Family and Medical Leave (PFML), administered by Unum

Development Journey

• Insights Discovery training for every employee to make the most of workplace relationships
• Ongoing professional development, including manager training
• Access to LinkedIn Leaning, a self-guided online education platform